However, point estimates for the relative risk in the rofecoxib group as compared with the placebo group were particularly high among patients with a history of symptomatic atherosclerotic cardiovascular disease (9.59; 95 percent confidence interval, 1.36 to 416) relative to those without such a clinical history (1.58; 95 percent confidence interval, 0.95 to 2.64; P for interaction = 0.096). La Deputazione Municipale stanziò allora 30 lire imperiali per far preparare un busto reliquiario, che secondo la tradizione doveva esprimere visivamente il tipo di reliquia contenuta. An independent, external safety-monitoring board met periodically to review safety data provided by a statistician who was aware of patients' study-group assignments. For each eligible event, source documents were collected and sent to the cardiac, cerebrovascular, or peripheral vascular adjudication committee. Nonsteroidal antiinflammatory drugs (NSAIDs) alleviate pain and inflammation but may cause gastrointestinal ulceration and bleeding, presumably by inhibiting cyclooxygenase (COX)-mediated production of prostaglandins. A high cardiovascular risk was defined by a history of symptomatic atherosclerotic cardiovascular disease or the presence of at least two of the following risk factors for coronary artery disease: a history of hypertension, a history of hypercholesterolemia, a history of diabetes, or current cigarette use. if ( objectWidth < parentWidth ) { Anderson Cancer Center, Houston (R.S.B. Movimento per la vita – La vita umana, un valore essenziale…. Morton, Queen Elizabeth Hospital, Edgbaston, United Kingdom; T.J. Myrhoj, J.R. Andersen, Hvidovre Hospital, Hvidovre, Denmark; A. Nakad, Hospital Notre Dame, Tournai, Belgium; V. Narayen, Gastrointestinal Diagnostic Center, Baltimore; Y. Niv, Rabin Medical Center, Petah Tikva, Israel; P.M. Pardoll, S. Scheinert, Center for Digestive Diseases, St. Petersburg, Fla.; C. Phino, J.M. } else { var bsaProContainer = $('.bsaProContainer-7'); Pantaleone pregò Dio di perdonarli, motivo per il quale egli ricevette pure il nome di Panteleemon (in lingua greca, colui che di tutti ha compassione). Baerg, Tacoma Digestive Disease Center, Tacoma, Wash.; H. Baistrocchi, Unidad de Aparato Digestivo Julio Dante Baistrocchi, Cordoba, Argentina; M.L. var number_hide_ads = "0"; Written informed consent was obtained from all patients. Holt, D.P. Other investigator-reported cardiovascular events known to be associated with NSAID use, such as congestive heart failure and pulmonary edema, although less well defined, occurred earlier (at approximately five months) and at a higher rate among patients taking rofecoxib than among those taking placebo. The increased relative risk became apparent after 18 months of treatment; during the first 18 months, the event rates were similar in the two groups. I benedettini furono nei secc. The mean arterial pressure throughout the study, included as a time-varying covariate, did not materially modify the treatment effect (relative risk for the comparison of the rofecoxib group with the placebo group, 1.87; 95 percent confidence interval, 1.14 to 3.06). E nel grande ciclo di affreschi della chiesa di S. Angelo in Formis a Capua, chiesa costruita da Desiderio, abate di Montecassino, poi papa Vittore III negli anni 1072-87, var bsaProContainer = $('.bsaProContainer-8'); Schmitt, Southern Clinical Research, Chattanooga, Tenn.; F. Macrae, Cabrini Hospital, Malvern, Australia; E.E. (function ($) { Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program. S. Pantaleone è un santo venerato anche nella tradizione liturgica di Venezia: qui sono arrivate reliquie, culto, arte dalla tradizione bizantina, per gli intensi contatti di Venezia con l'Oriente per motivi commerciali, poi con la conquista di Costantinopoli da parte dei Latini nella IV Crociata del 1204, e ancor più per la fuga dalla seconda Roma dopo la conquista musulmana di Maometto II nel 1453. There was earlier separation (at approximately five months) between groups in the incidence of nonadjudicated investigator-reported congestive heart failure, pulmonary edema, or cardiac failure (hazard ratio for the comparison of the rofecoxib group with the placebo group, 4.61; 95 percent confidence interval, 1.50 to 18.83). Barclay, Christchurch Hospital, Christchurch, New Zealand; C. Beglinger, University of Basel, Basel, Switzerland; G. Bianchi-Porro, Ospedale Luigi Sacco, Milan; T. Bolin, Prince of Wales Hospital, Randwick, Australia; R.M. Spouse of the Blessed Virgin Mary Legal father of Jesus Prince and Patron of the Universal Church; Venerated in: All Christian denominations which venerate saints: Feast: 19 March – Saint Joseph, Husband of Mary (Western Christianity) The third Wednesday after Easter Sunday-The Solemnity of Saint Joseph, spouse of the Blessed Virgin Mary and Patron of the Universal Church (Roman Catholic Church) Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. Cyclooxygenase-2-specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Schubert, Allenmore Medical Center, Tacoma, Wash.; H.I. Baron JA, Cole BF, Sandler RS, et al. var parentWidth = "324"; A total of 2586 patients with a history of colorectal adenomas underwent randomization: 1287 were assigned to receive 25 mg of rofecoxib daily, and 1299 to receive placebo. Howard PA, Delafontaine P. Nonsteroidal anti-inflammatory drugs and cardiovascular risk. Nel 1836 il busto reliquiario rinascimentale venne fuso a causa del suo pessimo stato per comporre un nuovo busto, appunto l'attuale. Eu, Singapore General Hospital, Singapore; N.R. Quindi ci si deve muovere in altra direzione per giustificare un culto che ha radici così antiche. setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); The Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial was designed to evaluate the hypothesis that three years of treatment with rofecoxib would reduce the risk of recurrent adenomatous polyps among patients with a history of colorectal adenomas. One analysis summarized the relative risk of confirmed serious thrombotic adverse events according to the quartiles of change in mean arterial pressure at week 4. However, if there were fewer than 11 events in either group, the rate ratio was computed with the use of the binomial distribution.24 A test of the proportional-hazards assumption was specified in the cardiovascular-analysis plan. Vakil, Aurora Sinai Medical Center, Milwaukee; P.R. if ( objectWidth > 0 && objectWidth != 100 && scale > 0 ) { Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. Arch Intern Med 2002;162:1105-1110[Erratum, Arch Intern Med 2002;162:1779. report that patients who received parecoxib and valdecoxib for pain in the first 10 days after coronary-artery bypass grafting had an increased risk of cardiovascular events during 30 days of follow-up.28 Also in this issue, Solomon et al. })(jQuery); (function(d, s, id) { Information, resources, and support needed to approach rotations - and life as a resident. Bombardier C, Laine L, Reicin A, et al. Venne scelto come patrono dalla comunità civile cremasca dopo la sua misteriosa apparizione sulla città per liberarla dalla pestilenza il 10 giugno 1361. Address reprint requests to Dr. Bresalier at the Department of Gastrointestinal Medicine and Nutrition, University of Texas M.D. Provenza, Louisiana Research Center, Shreveport; W.S. Badia, Hospital Clinic I Provincial, Barcelona, Spain; R.D. Fugarolas, J.F. Bresalier, R.S. Risk of acute myocardial infraction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study. Lower risk of thromboembolic cardiovascular events with naproxen among patients with rheumatoid arthritis. }); setTimeout(function () { bsaProContainer.fadeOut(); }, number_hide_ads * 1000); N Engl J Med 2005;352:1071-1080. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care. Other relevant but not independently adjudicated events were also analyzed, including hypertension-related events, edema-related events, and the combined end point of congestive heart failure, pulmonary edema, or cardiac failure. Dr. Baron also reports having served as an unpaid consultant to Bayer. Konstam MA, Weir MR, Reicin A, et al. Am J Epidemiol 1987;125:340-347, 25. In addition, there was an increased frequency of investigator-reported events, such as hypertension, edema, and congestive heart failure, which occurred much earlier in the study. Il Nuovo Torrazzo, tramite la Fisc (Federazione Italiana Settimanali Cattolici), ha aderito allo IAP (Istituto dell’Autodisciplina Pubblicitaria) accettando il Codice di Autodisciplina della Comunicazione Commerciale. var parentHeight = "600"; Harris, N.B. It is also not clear whether the partial inhibition of COX-1 by various nonselective NSAIDs offsets any adverse cardiovascular effects of COX-2 inhibition, since this possibility has not been evaluated explicitly in trials. Arch Intern Med 2003;163:481-486, 19. Il braccio. Stay connected to what's important in medical research and clinical practice, Subscribe to the most trusted and influential source ofmedical knowledge, A correction has been published Mamdani M, Rochon P, Juurlink DN, et al. These changes in blood pressure were observed early in the study, along with investigator-reported edema and congestive heart failure. ); the Department of Medicine, Clinic University Hospital, Zaragoza, Spain (A.L. ); the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill (R.S.S. An updated analysis that included data from various placebo-controlled studies investigating rofecoxib for the treatment or prevention of Alzheimer's disease did not demonstrate an excess of cardiovascular events associated with rofecoxib therapy.5 A recent meta-analysis comparing cardiovascular risk in trials that included various doses of rofecoxib suggested an increased relative risk among patients taking rofecoxib, as compared with those taking naproxen, but not placebo.22 Differences between our results and these earlier clinical-trial data may be related to differences in defined end points or the duration of treatment, a possibility supported by the apparent absence of a difference in adjudicated thrombotic events during the first 18 months of our study. Concomitant medications used at some time during the study included low-dose aspirin (in 20 percent of the rofecoxib group and 19 percent of the placebo group, P=0.52), antihypertensive drugs (44 percent and 36 percent, respectively; P<0.001), lipid-lowering agents (31 percent and 28 percent, respectively; P=0.09), antiplatelet agents such as clopidogrel (4 percent and 2 percent, respectively; P=0.003), insulin (3 percent and 2 percent, respectively; P=0.10), and oral hypoglycemic agents (13 percent and 11 percent, respectively; P=0.12). Ricorre oggi, 10 giugno, la festa per il Santo Patrono della Città di Crema, San Pantaleone. A randomized trial of aspirin to prevent colorectal adenomas. The study was terminated on September 30, 2004, approximately two months ahead of the planned date of completion, at the recommendation of the external safety-monitoring board and the steering committee. } })(jQuery); (function($){ if ( number_show_ads > 0 ) { Graham DJ, Campen D, Hui R, et al. Holt, Endoscopic Microsurgery Associates, Towson, Md. Il suo sangue (raccolto, secondo la tradizione risalente al XII secolo, da Adamantio, testimone del martirio) era originariamente conservato in un’unica e grande ampolla, custodita nella chiesa a lui dedicata (oggi monumento ai caduti) a Ravello. var objectWidth = object.width(); Adverse events occurring during the study were recorded and evaluated in a blinded fashion by the investigators. Come è arrivato a Crema il culto di S. Pantaleone? COX-2 inhibitors have been widely used as antiinflammatory and pain-relief agents and may hold promise as chemopreventive agents for a variety of epithelial cancers. Rex, Indiana University Hospital, Indianapolis; F.P. There were 10 deaths in each group. Overall and cardiovascular mortality was similar in the two groups. CAPITALE SOCIALE Euro 100.000,00 i.v. innerThumb.height(parentHeight * scale); ], 24. Elsewhere in this issue of the Journal, Nussmeier et al. Nel 1486, in occasione del prolungamento del coro del Duomo, demolendosi l'altare, fu trovata una cassettina d'avorio, ora scomparsa, piena di reliquie, tra le quali una parte del cranio di S. Pantaleone. It is unclear whether the results seen with rofecoxib represent a general effect of COX-2 inhibitors or a specific effect of rofecoxib. BMJ 1994;308:81-106[Erratum, BMJ 1994;308:1540. var js, fjs = d.getElementsByTagName(s)[0]; The most trusted, influential source of new medical knowledge and clinical best practices in the world. ; W. Harford, Veterans Affairs Medical Center, Dallas; S.M. report that an ongoing safety review of the Adenoma Prevention with Celecoxib Trial revealed that the risk of fatal or nonfatal cardiovascular events was increased by a factor of 2.3 among patients who were randomly assigned to receive celecoxib, as compared with those who were assigned to receive placebo,29 leading the National Cancer Institute to suspend the trial. March 17, 2005N Engl J Med 2005; 352:1092-1102 The investigators had full and unfettered access to the data. Baseline Characteristics of the Patients. Itzkowitz, Mount Sinai Medical Center, New York; R.F. Association between naproxen use and protection against acute myocardial infarction. Guess HA, Lydick EG, Small RD, Miller LP. bsaProResize(); innerThumb.height(parentHeight * scale); if ( number_hide_ads > 0 ) { Calcio Serie C: terza vittoria stagionale per la Pergolettese! The following persons and institutions participated in the APPROVe Trial: Steering Committee — J.A. 93069360209, L’Associazione ha come scopo la valorizzazione e la divulgazione della conoscenza della cultura della Lombardia nonché della sua storia e la tutela del suo territorio, Posted @withregram • @lago_di_como_official Un m, Posted @withregram • @paolabrunoli_ Quando arriv, Posted @withregram • @giammj33 Buona serata, Posted @withregram • @antonella_corengia Uncondi, Posted @withregram • @campisano.nicola / Non bas, Posted @withregram • @_pbarone Ponte Coperto di, Posted @withregram • @jessys_travels E a proposi, Posted @withregram • @paolabrunoli_ Via dei terr. }); js.src = "//connect.facebook.net/it_IT/sdk.js#xfbml=1&version=v2.9&appId=292842171096488"; Tepper, Long Island Clinical Research Associates, Great Neck, N.Y.; R. Estela, Hospital Clinico San Borja-Arriaran, Santiago, Chile; M. Färkkilä, University Central Hospital, Helsinki; G.M. The changing pattern of the treatment effect over time was confirmed by a failed test for proportionality of hazards (P=0.01). In our randomized, placebo-controlled trial, we found an increased risk of confirmed thrombotic events associated with the long-term use of rofecoxib. Yudelman, Digestive Health Physicians, Fort Myers, Fla.; B.C.Y. setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); var innerThumb = $(".bsaProContainer-" + sid + " .bsaProItemInner__thumb"); 166 -170 , Sep 16-18, 2002 Conference 360 Dr. Konstam reports having received consulting fees from Merck. }); At the time of termination, a total of 877 patients in the rofecoxib group and 980 patients in the placebo group had completed the scheduled three years of treatment. The two groups were generally similar with regard to baseline characteristics, including age, sex, use or nonuse of low-dose aspirin, and cardiovascular-risk status (Table 1). imported by the patrÓn spirits company, coral gables, fl., usa tequila – 40% alc. function bsaProResize() { This model was used to investigate the association of the change in blood pressure over time with the occurrence of confirmed serious thrombotic events. if ( objectWidth > 0 && objectWidth != 100 && scale > 0 ) { ); Merck Research Laboratories, West Point, Pa. setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); Only the 1000 most recent citing articles are listed here. ); the Department of Surgery, University of Birmingham, Birmingham, United Kingdom (D.M. Il Nuovo Torrazzo fruisce dei contributi statali diretti di cui alla Legge 7 agosto 90 n. 250. }); No formal stopping rule was specified for terminating the study. Cleland, Montreal General Hospital, Montreal; G. Costamagna, Universita Cattolica del Sacro Cuore, Rome; P. Crone, Kobenhavns Amtssygehus i Glostrup, Glostrup, Denmark; E.V. function bsaProResize() { animateThumb.height(parentHeight); Potential thrombotic events were adjudicated by an independent committee, and all safety data were monitored by an external safety-monitoring committee. object.height(parentHeight); Ha subito il martirio nel 305 sotto l'imperatore Galerio. In this randomized, placebo-controlled, double-blind trial, we found that long-term use of the COX-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular events. Marcon, Toronto; R.D. (function ($) { Venendo i Benedettini di Montecassino a Crema nel 1097 dovettero portare nel programma dell'ora et labora anche la devozione significativa del Monastero di Montecassino, cioè la devozione a San Pantaleone. The increase in adjudicated thrombotic events associated with rofecoxib therapy was not evident during the first 18 months of the trial. ], 11. NEW! Tradizioni e folclore dell’Alto Mantovano, La Lombardia guida la transizione verso un futuro “Green” e sostenibile, Sanità: gli ospedali lombardi al top nel mondo per la classifica di Newsweek, In ricordo di VICO MAGISTRETTI nel centenario dalla nascita. Il Martirologio romano fissa per la memoria di san Pantaleone la data del 27 luglio. L’ampolla conservata nel duomo di Ravello presenta il fenomeno dell’annuale liquefazione del sangue, che avviene nel mese di luglio o in occasione di miracoli ottenuti dal santo. setTimeout(function () { bsaProContainer.fadeOut(); }, number_hide_ads * 1000); Marks, Alabama Digestive Research Center, Alabaster; C.E. Mean arterial pressure did not appear to have a significant association with confirmed thrombotic events, however, according to an assessment of changes from baseline to four weeks and an analysis that included mean arterial pressure as a time-varying covariate in a model of treatment effects. var animateThumb = $(".bsaProContainer-" + sid + " .bsaProAnimateThumb"); Indiano deferito, Cremasco – Droga nascosta in bottiglia con doppio fondo, 30enne nuovamente…, Prefettura – Spostamenti da Comune a Comune consentiti per…, Dovera – Infortunio sul lavoro, 18enne in ospedale, GIORNATA DELLA PREMATURITÀ – Il balcone del Comune s’illumina di viola, COVID-19 – Piloni (Pd): “Rimborso totale a Rsa e Rsd, ma…, A breve partiranno i lavori di ristrutturazione al bocciodromo di Crema, TAVOLO STRATEGICO – Avviato anche per il socio sanitario per strategie…, Lutto in Comune per la prematura scomparsa di Davide Fusar Bassini, Palazzo Pignano – “Insieme per la Pieve”: rassegna rinviata in attesa…, CORONAVIRUS – I dati del 17 novembre: +8.448 casi in regione,…, Bagnolo Cremasco – Autunno di grandi lavori pubblici in paese: riqualificazione,…, Coronavirus – I dati di oggi in Lombardia: +14.231 guariti-dimessi e…, Madignano – Guerrini Rocco torna ai Servizi sociali. object.height(parentHeight * scale); Weir MR, Sperling RS, Reicin A, Gertz BJ. object.height(parentHeight * scale); Secondo la Passio era un cristiano, medico personale del cesare Galerio, che subì il martirio durante le persecuzioni di Diocleziano: patrono dei medici (insieme ai santi Cosma e Damiano) e delle ostetriche, è venerato come santo da numerose Chiese cristiane ed è considerato uno dei quattordici santi ausiliatori (viene invocato contro le infermità di consunzione). McQuaid, Veterans Affairs Medical Center, San Francisco; G. Minoli, Ospedale Valduce Reparto, Como, Italy; M. Montoro, Hospital San Jorge, Huesca, Spain; A. Montoya, Clinica Shaio, Bogota, Colombia; G. Morelli, Optimum Clinical Research, Montreal; D.G. Drs. if ( number_hide_ads > 0 ) { Participating investigators are listed in the Appendix. Crema fu parte della Repubblica di Venezia per tre secoli e mezzo, 1449-1797. Pantaleone, però, confessò apertamente la sua fede e, per mostrare di essere nel giusto, risanò un paralitico: ciò nonostante, egli fu dapprima condannato al rogo, ma le fiamme si spensero, poi ad essere immerso nel piombo fuso, ma il piombo si raffreddò miracolosamente; a questo punto Pantaleone fu gettato in mare con una pietra legata al collo, ma il masso prese a galleggiare; venne condannato ad feras, ma le belve che avrebbero dovuto sbranarlo si misero a fargli le feste; fu poi legato ad una ruota, ma le corde si spezzarono e la ruota andò in frantumi. Am J Ther 2001;8:85-95[Erratum, Am J Ther 2001;8:220. Pressman, San Diego Digestive Disease Consultants, San Diego, Calif.; V. Prochazka, Fakultni Nemocnice Olomouc, Olomouc, Czech Republic; J.M. } Information and tools for librarians about site license offerings. Calcio a 5: protesta pacifica del Videoton prima della partita, Calcio Serie C: la nebbia costringe al rinvio la Pergolettese, IV Giornata mondiale dei poveri – Papa Francesco: “La più grande povertà da combattere è la nostra povertà d’amore”, Diocesi di Butembo Beni – Mons. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. Piazza Duomo, 25 26013 Crema (CR) Tel. Juni P, Nartey L, Reichenbach S, Sterchi R, Dieppe PA, Egger M. Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Men and women who were at least 40 years old were eligible if they had had at least one histologically confirmed large-bowel adenoma removed within 12 weeks before study entry and were not anticipated to need long-term NSAID therapy (including high-dose aspirin) during the study. It was unclear how much of the increase in risk was due to a deleterious effect of high-dose rofecoxib, a protective effect of naproxen, chance, or a combination of these factors.26 A recent meta-analysis21 suggested that the magnitude of any cardioprotective effect of naproxen is unlikely to account entirely for these findings. È certamente la domanda che ancora oggi i Cremaschi si pongono. Calcio Serie C: Pergolettese, mister Contini rassegna le dimissioni, Calcio a 5: rinviata la partita del Videoton di domani. ], 16. Baron). innerThumb.height(parentHeight); var sid = "5"; C.F. Se continui ad utilizzare questo sito supponiamo che tu ne sia felice. Patients who took at least 80 percent of their tablets during the placebo run-in period were randomly assigned to receive either one 25-mg tablet of rofecoxib per day (the maximal recommended long-term daily dose) or one identical-appearing placebo tablet per day for three years. Solomon DH, Schneeweiss S, Glynn RJ, et al. })(jQuery); $(document).ready(function(){ LE RELIQUIE A retrospective cohort study that assessed the occurrence of serious coronary heart disease among NSAID users19 showed an elevated cardiovascular risk associated with the use of high-dose rofecoxib, but no increased risk with the use of doses of 25 mg or less. 1. bsaProResize(); var number_show_ads = "0"; 46010 San Martino dall’Argine Via Aldo Moro n.15 object.height(parentHeight); $(document).ready(function(){ Analysis of a database including 5435 patients with osteoarthritis in eight double-blind, placebo-controlled, phase 2B or phase 3 trials reported similar rates of thrombotic cardiovascular adverse events with rofecoxib, placebo, and various nonselective NSAIDs.5 A pooled analysis of data from more than 28,000 patients with various diseases (representing more than 14,000 patient-years at risk) from 23 previous trials of rofecoxib (phase 2B through phase 5), including patients from the VIGOR trial, also did not demonstrate a significant increase in cardiovascular risk for rofecoxib as compared with placebo or NSAIDs other than naproxen.4 This analysis used the APTC end point we evaluated. Case Records of the Massachusetts General Hospital, American Heart Association Scientific Sessions, Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease, Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure, Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation, Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation, Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis, Evinacumab in Patients with Refractory Hypercholesterolemia, A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis, Case 35-2020: A 59-Year-Old Woman with Type 1 Diabetes Mellitus and Obtundation, Intussusception after Rotavirus Vaccine Introduction in India, for the Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators. the perfect way to enjoy patrÓn is responsibly. All patients who underwent randomization and took at least one dose of study medication were included in the analyses. } Incidence of Nonadjudicated Cardiovascular Adverse Events. Collaborative overview of randomised trials of antiplatelet therapy. AUGURI A TUTTI I CREMASCHI. The overall risk did not appear to be significantly influenced by baseline or subsequent use of low-dose aspirin. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. ; R.W. Kimmel SE, Berlin JA, Reilly M, et al. Sul monte Athos, Grecia, il monastero della comunità russa, uno dei venti ancora oggi esistenti sulla santa montagna, è a lui dedicato (monastero di San Panteleimon). Wong, University of Hong Kong Queen Mary Hospital, Hong Kong; J.P. Wright, Kinsbury Hospital, Claremont, South Africa; A. Zambelli, Ospedale Maggiore Azienda Ospedaliera, Crema, Italy. Johanson, Rockford Gastroenterology Associates, Rockford, Ill.; P.W. } else { Whelton A, White WB, Bello AE, Puma JA, Fort JG. Schoen, University of Pittsburgh Medical Center, Pittsburgh; T.T. var number_hide_ads = "0"; Kaplan–Meier Estimates of the Cumulative Incidence of Confirmed Serious Thrombotic Events. CULTURA CREMA – La proposta prosegue, sempre intensa, online! Ricorre oggi, 10 giugno, la festa per il Santo Patrono della Città di Crema, San Pantaleone. Mamdani M, Juurlink DN, Lee DS, et al. Vertical lines indicate 95 percent confidence intervals. The content of this site is intended for health care professionals. Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism. setTimeout(function () { bsaProContainer.fadeOut(); }, number_hide_ads * 1000); Schwartz, Miami Research Associates, Miami; E. Segal, Hospital General de Agudos Carlos G. Durand, Buenos Aires; F. Seow-Choen, K.W. – R.I. Cremona 00351480199 – NUMERO REA CR – 99726 Come ipotesi personale propongo la via che passa attraverso i Benedettini di Montecassino che giunsero a Crema, a S. Benedetto, nel dicembre 1097. Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial. As compared with the placebo group, the rofecoxib group had an increased risk of confirmed thrombotic events (relative risk, 1.92; 95 percent confidence interval, 1.19 to 3.11). D'Haens, Imeldaziekenhuis, Bon Heiden, Belgium; W. Dekker, J. Ferwerda, Kennemer Gasthuis, Haarlem, the Netherlands; E. Dominguez-Munoz, Hospital de Conxo, La Coruna, Spain; D.S. S. Pantaleone occupa un posto di particolare dignità. Also, the relative risk in the rofecoxib group as compared with the placebo group was 6.10 among patients with a history of diabetes (95 percent confidence interval, 1.36 to 56.1), in contrast to a relative risk of 1.55 among patients with no history of diabetes (95 percent confidence interval, 0.92 to 2.61; P for interaction = 0.091).
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